A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of glaucoma
ncRNA name cZNF609
ncRNA Category circRNA
Disease name glaucoma
Species Rattus norvegicus
Tissues/Cell_line retinas; rat Müller cell line rMC-1
Methods qRT-PCR, Sanger sequencing, immunofluorescence staining, MTT assay, Ki67 staining, PI staining
Expression pattern up-regulated
Functional description cZNF609 silencing reduced retinal reactive gliosis and glial cell activation, and facilitated RGC survival in vivo. cZNF609 silencing directly regulated Müller cell function but indirectly regulated RGC function in vitro. cZNF609 acted as an endogenous miR-615 sponge to sequester and inhibit miR-615 activity, which led to increased METRN.
PubMed ID 29930739
Year 2018
Title Circular RNA-ZNF609 regulates retinal neurodegeneration by acting as miR-615 sponge.
Drug-related ncRNA NA

Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.