| ncRNA name | cZNF609 |
| ncRNA Category | circRNA |
| Disease name | glaucoma |
| Species | Rattus norvegicus |
| Tissues/Cell_line | retinas; rat Müller cell line rMC-1 |
| Methods | qRT-PCR, Sanger sequencing, immunofluorescence staining, MTT assay, Ki67 staining, PI staining |
| Expression pattern | up-regulated |
| Functional description | cZNF609 silencing reduced retinal reactive gliosis and glial cell activation, and facilitated RGC survival in vivo. cZNF609 silencing directly regulated Müller cell function but indirectly regulated RGC function in vitro. cZNF609 acted as an endogenous miR-615 sponge to sequester and inhibit miR-615 activity, which led to increased METRN. |
| PubMed ID | 29930739 |
| Year | 2018 |
| Title | Circular RNA-ZNF609 regulates retinal neurodegeneration by acting as miR-615 sponge. |
| Drug-related ncRNA | NA |
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