| ncRNA name | cZRANB1 |
| ncRNA Category | circRNA |
| Disease name | glaucoma |
| Species | Rattus norvegicus |
| Tissues/Cell_line | retinas; rat Müller cell line rMC-1 |
| Methods | immunohistochemistry, qRT-PCR, co-culture assay |
| Expression pattern | up-regulated |
| Functional description | cZRANB1 knockdown decreases retinal reactive gliosis, glial cell activation, and facilitates RGC survival in vivo. cZRANB1 knockdown directly regulates Müller cell function and indirectly regulates RGC function in vitro. cZRANB1 acts as miRNA sponge to regulate Müller cell function through cZRANB1/miR-217/RUNX2 network. |
| PubMed ID | 29748605 |
| Year | 2018 |
| Title | Targeting circular RNA-ZRANB1 for therapeutic intervention in retinal neurodegeneration. |
| Drug-related ncRNA | NA |
Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.