A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of glaucoma
ncRNA name cZRANB1
ncRNA Category circRNA
Disease name glaucoma
Species Rattus norvegicus
Tissues/Cell_line retinas; rat Müller cell line rMC-1
Methods immunohistochemistry, qRT-PCR, co-culture assay
Expression pattern up-regulated
Functional description cZRANB1 knockdown decreases retinal reactive gliosis, glial cell activation, and facilitates RGC survival in vivo. cZRANB1 knockdown directly regulates Müller cell function and indirectly regulates RGC function in vitro. cZRANB1 acts as miRNA sponge to regulate Müller cell function through cZRANB1/miR-217/RUNX2 network.
PubMed ID 29748605
Year 2018
Title Targeting circular RNA-ZRANB1 for therapeutic intervention in retinal neurodegeneration.
Drug-related ncRNA NA

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