A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of glaucoma
ncRNA name A2AR siRNA
ncRNA Category siRNA
Disease name glaucoma
Species Mus musculus
Tissues/Cell_line mouse microglia cell line BV-2
Methods siRNA transfection, phagocytosis assay, scratch wound assay, Boyden chamber migration assay, qPCR
Expression pattern associated
Functional description The A2A R antagonist SCH 58261 or the knockdown of A2A R expression with siRNA in microglial cells prevented the increase in microglia response to elevated hydrostatic pressure.
PubMed ID 30667095
Year 2019
Title Blockade of microglial adenosine A2A receptor suppresses elevated pressure-induced inflammation, oxidative stress, and cell death in retinal cells.
Drug-related ncRNA NO

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