| ncRNA name | RhoA siRNA |
| ncRNA Category | siRNA |
| Disease name | glaucoma |
| Species | Rattus norvegicus |
| Tissues/Cell_line | retinas |
| Methods | siRNA injection, qRT-PCR, immunohistochemistry |
| Expression pattern | associated |
| Functional description | TGF-β caused increased TM contractile proteins and IOP spikes by day 7, sustained increases in IOP from day 15, and TM fibrosis at day 35. siRhoA abolished the transient 7 day IOP rise but not the later sustained IOP increase (due to fibrosis). At 35 days, TGF-β-related RGC loss was not prevented with siRhoA treatment. |
| PubMed ID | 30429640 |
| Year | 2018 |
| Title | TGF-β-induced IOP elevations are mediated by RhoA in the early but not the late fibrotic phase of open angle glaucoma. |
| Drug-related ncRNA | NO |
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