|primary human trabecular meshwork cells
|siRNA transfection, flow cytometry, qPCR, Western blot, apoptosis assay
|It is known that the extracellular matrix (ECM) of the trabecular meshwork, oxidative stress, TGFβ signaling pathways, and apoptosis are important components of glaucoma pathogenesis.We found that oxidative stress induction and LTBP2 knockdown both affected all the processes queried, and that their affects paralleled one another.
|LTBP2 knockdown and oxidative stress affect glaucoma features including TGFβ pathways, ECM genes expression and apoptosis in trabecular meshwork cells.
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