A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of glaucoma
ncRNA name LTBP2 siRNA
ncRNA Category siRNA
Disease name glaucoma
Species Homo sapiens
Tissues/Cell_line primary human trabecular meshwork cells
Methods siRNA transfection, flow cytometry, qPCR, Western blot, apoptosis assay
Expression pattern associated
Functional description It is known that the extracellular matrix (ECM) of the trabecular meshwork, oxidative stress, TGFβ signaling pathways, and apoptosis are important components of glaucoma pathogenesis.We found that oxidative stress induction and LTBP2 knockdown both affected all the processes queried, and that their affects paralleled one another.
PubMed ID 29908281
Year 2018
Title LTBP2 knockdown and oxidative stress affect glaucoma features including TGFβ pathways, ECM genes expression and apoptosis in trabecular meshwork cells.
Drug-related ncRNA NO

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