A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of glaucoma
ncRNA name beta2 adrenergic receptor siRNA
ncRNA Category siRNA
Disease name glaucoma
Species Oryctolagus cuniculus
Tissues/Cell_line eyes
Methods siRNA instillation, IOP measurements
Expression pattern associated
Functional description siRNA designed for beta2 adrenergic receptor induced a reduction of intraocular pressure of 30±5%, compared to a control. The results in terms of IOP decrease were similar to that found with commercial compounds but a long-lasting hypotensive action was shown by beta2 adrenergic receptor siRNA treatment as compared to commercial drugs.
PubMed ID 29132913
Year 2018
Title Beta2 adrenergic receptor silencing change intraocular pressure in New Zealand rabbits.
Drug-related ncRNA NO

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