A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of glaucoma
ncRNA name ATF3 siRNA
ncRNA Category siRNA
Disease name glaucoma
Species Mus musculus
Tissues/Cell_line retinal ganglion cell line RGC-5
Methods siRNA transfection, flow cytometry, qPCR, Western blot
Expression pattern associated
Functional description ATF3 specific siRNA effectively down-regulated ATF3 expression and significantly inhibited cell apoptosis in RGC-5 cells. Quantitative real-time PCR and Western blot confirmed that ATF3 knockdown remarkably decreased Jun-B and increased c-Jun at both mRNA and protein levels in RGC-5 cells.
PubMed ID 28546922
Year 2017
Title Effect of ATF3-deletion on apoptosis of cultured retinal ganglion cells.
Drug-related ncRNA NO

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