A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of fungal keratitis
ncRNA name PTX3 siRNA
ncRNA Category siRNA
Disease name fungal keratitis
Species Homo sapiens
Tissues/Cell_line human corneal epithelial cell (HCECs)
Methods siRNA transfection, immunochemistry, qRT-PCR, Western blot, ELISA
Expression pattern associated
Functional description PTX3 plays a proinflammatory role in corneal epithelial anti-fungi immune response by affecting the production of IL-1β and activation of some proinflammatory signaling pathways (ERK1/2 and JNK). Blocking of endogenous PTX3 by siRNA down-regulated the production of IL-1β at both mRNA and protein levels.
PubMed ID 27889356
Year 2018
Title Role of PTX3 in corneal epithelial innate immunity against Aspergillus fumigatus infection.
Drug-related ncRNA NO

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