|human corneal epithelial cell (HCECs)
|siRNA transfection, immunochemistry, qRT-PCR, Western blot, ELISA
|PTX3 plays a proinflammatory role in corneal epithelial anti-fungi immune response by affecting the production of IL-1β and activation of some proinflammatory signaling pathways (ERK1/2 and JNK). Blocking of endogenous PTX3 by siRNA down-regulated the production of IL-1β at both mRNA and protein levels.
|Role of PTX3 in corneal epithelial innate immunity against Aspergillus fumigatus infection.
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