A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of fungal keratitis
ncRNA name Chi3l1 siRNA
ncRNA Category siRNA
Disease name fungal keratitis
Species Mus musculus
Tissues/Cell_line corneas
Methods ELISA, qPCR, immunohistochemistry, siRNA transfection
Expression pattern associated
Functional description While C. albicans keratitis was more severe in the corneas treated with Chi3l1 small interfering RNA (siRNA), corneas treated with recombinant CHI3L1 before C. albicans inoculation had markedly ameliorated keratitis, reduced fungal load, and decreased polymorphonucleocyte (PMN) infiltration in an interleukin 13 receptor α2 (IL-13Rα2)-dependent manner.
PubMed ID 26238714
Year 2015
Title Chitinase 3-Like 1 Promotes Candida albicans Killing and Preserves Corneal Structure and Function by Controlling Host Antifungal Responses.
Drug-related ncRNA NO

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