A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of fungal keratitis
ncRNA name TLR4 siRNA
ncRNA Category siRNA
Disease name fungal keratitis
Species Homo sapiens
Tissues/Cell_line telomerase-immortalized human corneal epithelial cells (THCEs)
Methods siRNA transfection, RT-PCR, Western blot, ELISA
Expression pattern associated
Functional description Treatment with TLR2- or TLR4-siRNA plasmid reduced TLR2 or TLR4 expression level in THCE when compared with controls, and caused a significant decrease in A. fumigatus-induced IL-1beta and IL-6 production.
PubMed ID 19341426
Year 2009
Title Innate responses of corneal epithelial cells against Aspergillus fumigatus challenge.
Drug-related ncRNA NO

Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.