A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of fungal keratitis
ncRNA name TLR2 siRNA
ncRNA Category siRNA
Disease name fungal keratitis
Species Homo sapiens
Tissues/Cell_line telomerase-immortalized human stroma fibroblasts (THSF)
Methods siRNA transfection, immunofluorescence analysis, RT-PCR, Western blot, qPCR
Expression pattern associated
Functional description THSF transfected with TLR2-siRNA plasmid exhibited a reduced level of TLR2 when compared with the control cells transfected with empty plasmid. F. solu-stimulated IL-10 production by transfected THSF was severely impaired, while IL-1beta production was partially inhibited.
PubMed ID 18195725
Year 2008
Title Toll-like receptor 2 mediates the induction of IL-10 in corneal fibroblasts in response to Fusarium solu.
Drug-related ncRNA NO

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