|siRNA injection, qRT-PCR, Western blot, immunofluorescent staining, ELISA, histopathological examination
|In A. fumigatus-infected corneas, mature dendritic cells secreted Th2-attracting chemokines, the thymus and activation-regulated chemokine (TARC), and the macrophage-derived chemokine (MDC), encouraging the secretion of TNF-α and Th2 cytokine Interleukin (IL) -4, IL-5, and IL-13. The above processes were all restricted with subconjunctivally injection of TSLP siRNA.
|TSLP-activated dendritic cells induce T helper type 2 inflammation in Aspergillus fumigatus keratitis.
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