A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of fungal keratitis
ncRNA name TSLP siRNA
ncRNA Category siRNA
Disease name fungal keratitis
Species Mus musculus
Tissues/Cell_line corneas
Methods siRNA injection, qRT-PCR, Western blot, immunofluorescent staining, ELISA, histopathological examination
Expression pattern associated
Functional description In A. fumigatus-infected corneas, mature dendritic cells secreted Th2-attracting chemokines, the thymus and activation-regulated chemokine (TARC), and the macrophage-derived chemokine (MDC), encouraging the secretion of TNF-α and Th2 cytokine Interleukin (IL) -4, IL-5, and IL-13. The above processes were all restricted with subconjunctivally injection of TSLP siRNA.
PubMed ID 29550278
Year 2018
Title TSLP-activated dendritic cells induce T helper type 2 inflammation in Aspergillus fumigatus keratitis.
Drug-related ncRNA NO

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