A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of fungal keratitis
ncRNA name Dectin-1 siRNA
ncRNA Category siRNA
Disease name fungal keratitis
Species Mus musculus
Tissues/Cell_line corneas
Methods siRNA injection, RT-PCR, Western blot, immunofluorescence staining
Expression pattern associated
Functional description Pretreatment with Dectin-1 siRNA significantly decreased A. fumigatus-induced IL-1β production and JNK phosphorylation compared with scrambled control in C57BL/6 mice corneas.Dectin-1 induced IL-1β production is JNK dependent in mouse A. fumigatus keratitis, and suppressed apoptosis mediated anti-inflammatory response.
PubMed ID 28926773
Year 2017
Title Dectin-1 is essential for IL-1β production through JNK activation and apoptosis in Aspergillus fumigatus keratitis.
Drug-related ncRNA NO

Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.