A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of fungal keratitis
ncRNA name ISG15 siRNA
ncRNA Category siRNA
Disease name fungal keratitis
Species Mus musculus
Tissues/Cell_line corneas
Methods Cytokine ELISA, qPCR, Western blot, immunohistochemistry, siRNA injection
Expression pattern associated
Functional description SiRNA knockdown of ISG15 increased keratitis severity, dampened flagellin-induced protection, and greatly suppressed the expressions of ISGylation enzymes, IFN-γ, but not CXCL2 in B6 mouse CECs.
PubMed ID 28599020
Year 2017
Title ISG15 in Host Defense Against Candida albicans Infection in a Mouse Model of Fungal Keratitis.
Drug-related ncRNA NO

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