ncRNA name | ISG15 siRNA |
ncRNA Category | siRNA |
Disease name | fungal keratitis |
Species | Mus musculus |
Tissues/Cell_line | corneas |
Methods | Cytokine ELISA, qPCR, Western blot, immunohistochemistry, siRNA injection |
Expression pattern | associated |
Functional description | SiRNA knockdown of ISG15 increased keratitis severity, dampened flagellin-induced protection, and greatly suppressed the expressions of ISGylation enzymes, IFN-γ, but not CXCL2 in B6 mouse CECs. |
PubMed ID | 28599020 |
Year | 2017 |
Title | ISG15 in Host Defense Against Candida albicans Infection in a Mouse Model of Fungal Keratitis. |
Drug-related ncRNA | NO |
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