A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of diabetic retinopathy (DR)
ncRNA name p62/SQTSM1 siRNA
ncRNA Category siRNA
Disease name diabetic retinopathy (DR)
Species Rattus norvegicus
Tissues/Cell_line retinal Müller cell line rMC-1
Methods siRNA transfection, Western blot, immunofluorescence, immunoprecipitation, TUNEL assay, Acridine Orange staining
Expression pattern associated
Functional description High glucose induces increase of early and late autophagic markers, accumulation of p62/SQTSM1 and endoplasmic reticulum (ER) stress response associated with apoptosis augmentation. By silencing the p62/SQTSM1, ER stress is ameliorated (p<0.0001), preventing apoptosis.
PubMed ID 27564518
Year 2016
Title Defective Autophagy in Diabetic Retinopathy.
Drug-related ncRNA NO

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