A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of diabetic retinopathy (DR)
ncRNA name mmu-miR-451a
ncRNA Category miRNA
Disease name diabetic retinopathy (DR)
Species Mus musculus
Tissues/Cell_line retinas
Methods immunostaining, luciferase reporter assay, transfection, CCK-8 assay, wound healing assay, qRT-PCR, Western blot
Expression pattern down-regulated
Functional description miR-451a/ATF2 plays a vital role in the regulation of proliferation and migration in RPE cells through regulation of mitochondrial function, which may provide new perspectives for developing effective therapies for PDR.
PubMed ID 30576241
Year 2019
Title miRNA-451a regulates RPE function through promoting mitochondrial function in proliferative diabetic retinopathy.
Drug-related ncRNA NO

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