A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of diabetic retinopathy (DR)
ncRNA name hsa-miR-146b-3p
ncRNA Category miRNA
Disease name diabetic retinopathy (DR)
Species Homo sapiens
Tissues/Cell_line vitreous; human monocyte cell line U937; human RECs
Methods ELISA, immunofluorescence, qPCR, Western blot
Expression pattern down-regulated
Functional description Adenosine deaminase-2 is implicated in breakdown of the blood-retinal barrier (BRB) in DR through macrophages-derived cytokines. Inhibition of ADA2 by miR-146b-3p might be a useful tool to preserve BRB function in DR.
PubMed ID 28170537
Year 2017
Title Adenosine Deaminase-2-Induced Hyperpermeability in Human Retinal Vascular Endothelial Cells Is Suppressed by MicroRNA-146b-3p.
Drug-related ncRNA NO

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