A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of diabetic retinopathy (DR)
ncRNA name Cx43 siRNA
ncRNA Category siRNA
Disease name diabetic retinopathy (DR)
Species Rattus norvegicus
Tissues/Cell_line rat retinal endothelial cells (RRECs)
Methods siRNA transfection, Western blot, Co-immunoprecipitation, immunostaining
Expression pattern associated
Functional description Cells transfected with Cx43 siRNA and grown in N medium showed significant downregulation in occludin and ZO-1 expression, and exhibited increased cell monolayer permeability.
PubMed ID 24008412
Year 2013
Title Effects of high glucose-induced Cx43 downregulation on occludin and ZO-1 expression and tight junction barrier function in retinal endothelial cells.
Drug-related ncRNA NO

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