A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of diabetic retinopathy (DR)
ncRNA name ERK5 siRNA
ncRNA Category siRNA
Disease name diabetic retinopathy (DR)
Species Homo sapiens
Tissues/Cell_line human microvascular endothelial cells (HMVECs), human retinal microvascular endothelial cells (HRMECs)
Methods siRNA transfection, qRT-PCR, Western blot, ELISA
Expression pattern associated
Functional description Fibronectin (FN) production and deposition in the tissue is a characteristic feature of diabetic retinopathy. ERK5 is a recent member of the mitogen activated protein kinase (MAPK) family. siERK5 treatment led to an increase of FN synthesis. siERK5 transfection enhanced TGFβ1 mRNA expression.
PubMed ID 23188731
Year 2012
Title ERK5 Regulates glucose-induced increased fibronectin production in the endothelial cells and in the retina in diabetes.
Drug-related ncRNA NO

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