A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of diabetic retinopathy (DR)
ncRNA name hsa-miR-23b-3p
ncRNA Category miRNA
Disease name diabetic retinopathy (DR)
Species Homo sapiens
Tissues/Cell_line human retinal endothelial cells (HRECs)
Methods microarray, qRT-PCR, luciferase reporter assay, Chromatin immunoprecipitation (CHIP), in situ hybridisation
Expression pattern up-regulated
Functional description High glucose increased miR-23b-3p expression, even after the return to normal glucose. Luciferase assays identified SIRT1 as a target mRNA of miR-23b-3p. Reduced miR-23b-3p expression inhibited Ac-NF-κB expression by rescuing SIRT1 expression and also relieved the effect of metabolic memory induced by high glucose in HRECs.
PubMed ID 26687158
Year 2016
Title miR-23b-3p induces the cellular metabolic memory of high glucose in diabetic retinopathy through a SIRT1-dependent signalling pathway.
Drug-related ncRNA NO

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