A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of diabetic retinopathy (DR)
ncRNA name hsa-miR-126
ncRNA Category miRNA
Disease name diabetic retinopathy (DR)
Species Homo sapiens
Tissues/Cell_line human retinal pericytes (HRP)
Methods qRT-PCR, Western blot, FACS
Expression pattern down-regulated
Functional description HRP express miR-126, and this expression is down-regulated in intermittent high glucose. MSC-derived EV obtained in hyperglycaemic/hypoxic conditions down-regulate miR-126 expression in pericytes, leading to increased expression of angiogenic molecules, such as VEGF and HIF-1α.
PubMed ID 26282100
Year 2015
Title Molecular mechanisms of extracellular vesicle-induced vessel destabilization in diabetic retinopathy.
Drug-related ncRNA NO

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