A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of diabetic retinopathy (DR)
ncRNA name KChIP3 siRNA
ncRNA Category siRNA
Disease name diabetic retinopathy (DR)
Species Rattus norvegicus
Tissues/Cell_line Müller cells
Methods immunostaining, TUNEL assay, Western blot, Co-immunoprecipitation, Electrophysiology, siRNA transfection
Expression pattern associated
Functional description SiRNA analysis in Müller cells cultures grown under high glucose experimental conditions corroborated that, when the expression of KChIP3 is 50% reduced, the number of cells expressing A type currents decreases significantly.
PubMed ID 22277672
Year 2012
Title Hyperglycemia induces early upregulation of the calcium sensor KChIP3/DREAM/calsenilin in the rat retina.
Drug-related ncRNA NO

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