A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of diabetic retinopathy (DR)
ncRNA name LRP6 siRNA
ncRNA Category siRNA
Disease name diabetic retinopathy (DR)
Species Homo sapiens
Tissues/Cell_line human RPE cell line ARPE-19
Methods siRNA transfection, luciferase reporter assay, RT-PCR, confocal microscopy, ELISA, Western blot, immunoprecipitation, immunoblot
Expression pattern associated
Functional description Knockdown of LRP6 by an LRP6-specific siRNA decreased PEDF-FITC signal on the cells, suggesting that LRP6 is essential for binding of PEDF to the cells.
PubMed ID 21576363
Year 2011
Title Identification of a novel inhibitor of the canonical Wnt pathway.
Drug-related ncRNA NO

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