A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of diabetic retinopathy (DR)
ncRNA name hsa-miR-200b
ncRNA Category miRNA
Disease name diabetic retinopathy (DR)
Species Homo sapiens
Tissues/Cell_line human retinal microvascular endothelial cells
Methods qPCR, Western blot, ELISA, immunofluorescence
Expression pattern down-regulated
Functional description Glucose caused decreased expression of mRNA and protein levels of endothelial markers and increased expression of mesenchymal markers with reduced miR-200b. A glucose-like effect was seen using TGFβ1 peptide. Such changes were mediated by miR-200b and p300.
PubMed ID 25335984
Year 2014
Title Mechanisms of endothelial to mesenchymal transition in the retina in diabetes.
Drug-related ncRNA NO

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