A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of diabetic retinopathy (DR)
ncRNA name hsa-miR-495
ncRNA Category miRNA
Disease name diabetic retinopathy (DR)
Species Homo sapiens
Tissues/Cell_line human RPE cell line ARPE-19
Methods siRNA transfection, qRT-PCR, Western blot, luciferase reporter assay, immunohistochemistry
Expression pattern down-regulated
Functional description Overexpression of miR-20a, -20b, -17, -106a, -106b and -495 caused a significant downregulation of HIF1α and VEGF protein levels in ARPE cells exposed to HG+SIR.
PubMed ID 24018047
Year 2013
Title MicroRNA-dependent cross-talk between VEGF and HIF1α in the diabetic retina.
Drug-related ncRNA NO

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