A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of diabetic retinopathy (DR)
ncRNA name bta-miR-200b
ncRNA Category miRNA
Disease name diabetic retinopathy (DR)
Species Bos taurus
Tissues/Cell_line bovine retinal capillary ECs (BRECs)
Methods microarray, luciferase reporter assay, ELISA, tube formation assay, immunohistochemistry, in situ hybridization
Expression pattern down-regulated
Functional description In the retina, miR-200b was localized in neuronal, glial, and vascular elements. Transfection of endothelial cells and intravitreal injection of miR-200b mimic prevented diabetes-induced increased VEGF mRNA and protein. Also prevented were glucose-induced increased permeability and angiogenesis.
PubMed ID 21357793
Year 2011
Title MicroRNA-200b regulates vascular endothelial growth factor-mediated alterations in diabetic retinopathy.
Drug-related ncRNA NO

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