A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of diabetic retinopathy (DR)
ncRNA name NLRP3 shRNA
ncRNA Category shRNA
Disease name diabetic retinopathy (DR)
Species Rattus norvegicus
Tissues/Cell_line retinas
Methods shRNA knockdown, qRT-PCR, Western blot, caspase-3 assay, PI staining
Expression pattern associated
Functional description In high glucose-exposed HRMECs and retinas of diabetic rats, upregulated interleukin (IL)-1β maturation, IL-18 secretion, and caspase-1 cleavage were observed with increased cell apoptosis and retinal vascular permeability. NLRP3 silencing blocked these effects in the rat model and HRMECs.
PubMed ID 27785530
Year 2017
Title Activation of the TXNIP/NLRP3 inflammasome pathway contributes to inflammation in diabetic retinopathy: a novel inhibitory effect of minocycline.
Drug-related ncRNA NA

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