A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of diabetic retinopathy (DR)
ncRNA name OGT shRNA
ncRNA Category shRNA
Disease name diabetic retinopathy (DR)
Species Homo sapiens
Tissues/Cell_line human RPE cell line ARPE-19
Methods shRNA knockdown, ELISA, chromatin immunoprecipitation (ChIP), qRT-PCR, Western blot, immunoprecipitation
Expression pattern associated
Functional description Hyperglycemia increased VEGF-A promoter activity and upregulated VEGF-A transcript and protein. Cellular depletion of OGT or Sp1 by shRNA significantly abrogated glucose-induced changes in VEGF-A.
PubMed ID 25352121
Year 2014
Title O-GlcNAc modification of transcription factor Sp1 mediates hyperglycemia-induced VEGF-A upregulation in retinal cells.
Drug-related ncRNA NA

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