A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of diabetic retinopathy (DR)
ncRNA name KCNQ1OT1
ncRNA Category lncRNA
ID 10984
Ensembl ENSG00000269821
Synonyms LIT1; Kncq1; KvDMR1; KCNQ10T1; KCNQ1-AS2; KvLQT1-AS; NCRNA00012
Disease name diabetic retinopathy (DR)
Species Homo sapiens
Tissues/Cell_line human retinal endothelial cells (HRECs)
Methods CCK-8 assay, scratch assay, transwell assay, tube formation assay, Western blot, microarray, qRT‐PCR, flow cytometry, luciferase reporter assay
Expression pattern up-regulated
Functional description KCNQ1OT1 level was upregulated while microRNA-1470 (miR-1470) was decreased in DR patients and human retinal endothelial cells. KCNQ1OT1 could sponge miR-1470 and further regulate EGFR in DR.
PubMed ID 30784065
Year 2019
Title KCNQ1OT1 affects the progression of diabetic retinopathy by regulating miR-1470 and epidermal growth factor receptor.
Drug-related ncRNA NO

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