A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of diabetic retinopathy (DR)
ncRNA name Meg3
ncRNA Category lncRNA
ID 17263
Ensembl ENSMUSG00000021268
Synonyms 2900016C05Rik, 3110050O07Rik, 6330408G06Rik, D12Bwg1266e, Gtl2
Disease name diabetic retinopathy (DR)
Species Mus musculus
Tissues/Cell_line retinas
Methods qRT-PCR, transwell assay, siRNA transfection, Western blot and ELISA, PI/ Calcein-AM staining, Hoechst staining, immunofluorescence
Expression pattern down-regulated
Functional description MEG3 knockdown aggravates retinal vessel dysfunction in vivo, as shown by serious capillary degeneration, and increased microvascular leakage and inflammation. MEG3 knockdown also regulates retinal endothelial cell proliferation, migration, and tube formation in vitro. The role of MEG3 in endothelial cell function is mainly mediated by the activation of PI3k/Akt signaling.
PubMed ID 26845358
Year 2016
Title Long noncoding RNA-MEG3 is involved in diabetes mellitus-related microvascular dysfunction.
Drug-related ncRNA NO

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