A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of diabetic retinopathy (DR)
ncRNA name Miat
ncRNA Category lncRNA
ID 102552664
Ensembl NA
Synonyms NA
Disease name diabetic retinopathy (DR)
Species Rattus norvegicus
Tissues/Cell_line retinas
Methods TUNEL assay, qRT-PCR, Western blot, in situ hybridization, MTT assay, Hoechst staining, luciferase reporter assay, Calcein-AM and PI double staining
Expression pattern up-regulated
Functional description MIAT knockdown obviously ameliorated diabetes mellitus-induced retinal microvascular dysfunction in vivo, and inhibited endothelial cell proliferation, migration, and tube formation in vitro. MIAT functioned as a competing endogenous RNA, and formed a feedback loop with vascular endothelial growth factor and miR-150-5p to regulate endothelial cell function.
PubMed ID 25587098
Year 2015
Title lncRNA-MIAT regulates microvascular dysfunction by functioning as a competing endogenous RNA.
Drug-related ncRNA NO

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