A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of diabetic retinopathy (DR)
ncRNA name MALAT1
ncRNA Category lncRNA
ID 378938
Ensembl ENSG00000251562
Synonyms HCN, LINC00047, MALAT-1, NCRNA00047, NEAT2, PRO1073, mascRNA
Disease name diabetic retinopathy (DR)
Species Homo sapiens
Tissues/Cell_line aqueous humor, fibrovascular membranes
Methods microarray, qPCR
Expression pattern up-regulated
Functional description Approximately 303 lncRNAs were aberrantly expressed in the retinas of early DR, including 214 downregulated lncRNAs and 89 upregulated lncRNAs. In addition, MALAT1 was significantly upregulated in an RF/6A cell model of hyperglycemia, in the aqueous humor samples, and in fibrovascular membranes of diabetic patients.
PubMed ID 24436191
Year 2014
Title Aberrant expression of long noncoding RNAs in early diabetic retinopathy.
Drug-related ncRNA NO

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