A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of diabetic retinopathy (DR)
ncRNA name DDAH1 siRNA
ncRNA Category siRNA
Disease name diabetic retinopathy (DR)
Species Macaca mulatta
Tissues/Cell_line rhesus choroid-retinal endothelial cell line RF/6A
Methods tube formation assay, EdU incorporation assay, transwell assay, DAPI staining, siRNA transfection, high-performance liquid chromatography (HPLC), qRT-PCR, Western blot
Expression pattern associated
Functional description ADMA contributes to the neovascularization of retina in diabetic mellitus. After knocking down DDAH1 or DDAH2, the levels of ADMA were significantly increased. Knockdown of DDAH1 or DDAH2 also significantly increased the tube formation of RF/6A cells.
PubMed ID 29777874
Year 2018
Title Asymmetric dimethylarginine contributes to retinal neovascularization of diabetic retinopathy through EphrinB2 pathway.
Drug-related ncRNA NO

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