A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of diabetic cataract
ncRNA name AKR1B1 siRNA
ncRNA Category siRNA
Disease name diabetic cataract
Species Rattus norvegicus
Tissues/Cell_line lenses
Methods DNA sequencing, genotyping, RT-PCR, Western blot
Expression pattern associated
Functional description Aldose reductase (AKR1B1), which catalyzes the reduction of glucose to sorbitol and lipid aldehydes to lipid alcohols, has been shown to be involved in secondary diabetic complications including cataractogenesis. Rat lenses obtained from AKR1B1 knockdown rats were resistant to high glucose-induced lens opacification as compared to wild-type (WT) rat lenses.
PubMed ID 21376710
Year 2011
Title Aldose reductase deficiency protects sugar-induced lens opacification in rats.
Drug-related ncRNA NO

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