|choroidal neovascularization (CNV)
|immunoblot, siRNA injection, immunostaining, sprouting assay, NOS assay, TUNEL assay, qRT-PCR
|We identified the heme synthesis enzyme ferrochelatase (FECH) as necessary for angiogenesis in vitro and in vivo FECH is overexpressed in wet AMD eyes and murine choroidal neovascularization; siRNA knockdown of Fech or partial loss of enzymatic function in the Fechm1Pas mouse model reduces choroidal neovascularization.
|Ferrochelatase is a therapeutic target for ocular neovascularization.
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