A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of choroidal neovascularization (CNV)
ncRNA name FECH siRNA
ncRNA Category siRNA
Disease name choroidal neovascularization (CNV)
Species Homo sapiens
Tissues/Cell_line human retinal endothelial cells (HRECs)
Methods immunoblot, siRNA transfection, cell proliferation assay, migration assay, tube formation assay, immunostaining, sprouting assay, NOS assay, TUNEL assay, qRT-PCR
Expression pattern associated
Functional description We identified the heme synthesis enzyme ferrochelatase (FECH) as necessary for angiogenesis in vitro and in vivo FECH is overexpressed in wet AMD eyes and murine choroidal neovascularization; siRNA knockdown of Fech or partial loss of enzymatic function in the Fechm1Pas mouse model reduces choroidal neovascularization.
PubMed ID 28377496
Year 2017
Title Ferrochelatase is a therapeutic target for ocular neovascularization.
Drug-related ncRNA NO

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