A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of choroidal neovascularization (CNV)
ncRNA name PKR siRNA
ncRNA Category siRNA
Disease name choroidal neovascularization (CNV)
Species Macaca mulatta
Tissues/Cell_line human RPE cell line ARPE-19
Methods siRNA transfection, in vitro tube formation assay, Western blot, immunofluorescence, Fundus fluorescein angiography
Expression pattern associated
Functional description PKR promotes CNV formation via the PI3K/Akt signaling pathway in VEGF expression.In the ARPE-19 (RPE cell line) and RF/6A cell coculture system, PKR siRNA reduced the migration and tube formation of the RF/6A cells.
PubMed ID 27994435
Year 2016
Title PKR promotes choroidal neovascularization via upregulating the PI3K/Akt signaling pathway in VEGF expression.
Drug-related ncRNA NO

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