A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of choroidal neovascularization (CNV)
ncRNA name mmu-miR-188-5p
ncRNA Category miRNA
Disease name choroidal neovascularization (CNV)
Species Mus musculus
Tissues/Cell_line bone marrow-derived cells (BMCs), mesenchymal stem cells (MSCs)
Methods qRT-PCR, fluorescence in situ hybridization (FISH), luciferase reporter assay, Western blot, immunofluorescent staining, transfection, tube formation assay
Expression pattern down-regulated
Functional description miR-188-5p regulates the contribution of BMCs to CNV development by targeting MMP-2/13-mediated extracellular matrix degeneration, and miR-188-5p serves as a therapeutic target to treat CNV-related diseases.
PubMed ID 29908885
Year 2018
Title MicroRNA-188-5p regulates contribution of bone marrow-derived cells to choroidal neovascularization development by targeting MMP-2/13.
Drug-related ncRNA NO

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