A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of choroidal neovascularization (CNV)
ncRNA name hsa-miR-181a
ncRNA Category miRNA
Disease name choroidal neovascularization (CNV)
Species Homo sapiens
Tissues/Cell_line human retinal endothelial cells (HRECs) , human umbilical vein endothelial cells (HUVECs)
Methods illumina BeadCHIPs, [3H]-thymidine incorporation assay, apoptosis assay, tube formation assay, qRT-PCR
Expression pattern associated
Functional description The inhibition of miR-181a significantly abrogated the effect of LMPs on endothelial viability, but overexpression of miR-181a reduced endothelial cell viability in a dose-dependent manner. miR-181a strongly inhibited in vitro angiogenesis and ex vivo choroidal neovascularization.
PubMed ID 29608244
Year 2018
Title microRNA-181a inhibits ocular neovascularization by interfering with vascular endothelial growth factor expression.
Drug-related ncRNA NO

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