|choroidal neovascularization (CNV)
|human retinal endothelial cells (HRECs) , human umbilical vein endothelial cells (HUVECs)
|illumina BeadCHIPs, [3H]-thymidine incorporation assay, apoptosis assay, tube formation assay, qRT-PCR
|The inhibition of miR-181a significantly abrogated the effect of LMPs on endothelial viability, but overexpression of miR-181a reduced endothelial cell viability in a dose-dependent manner. miR-181a strongly inhibited in vitro angiogenesis and ex vivo choroidal neovascularization.
|microRNA-181a inhibits ocular neovascularization by interfering with vascular endothelial growth factor expression.
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