|choroidal neovascularization (CNV)
|human umbilical vein endothelial cells (HUVECs)
|siRNA transfection, qRT-PCR, ELISA, flow cytometry, Western blot
|The CRYAA siRNA not only induced HUVEC apoptosis but also inhibited exogenous and endogenous VEGF-induced cell activities, including proliferation, migration, and tube formation. In addition, CRYAA knockout led to increased levels of cleaved caspase-9 and caspase-3.
|Knockout of αA-crystallin inhibits ocular neovascularization.
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