A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of choroidal neovascularization (CNV)
ncRNA name miR(5,B,7)
ncRNA Category miRNA
Disease name choroidal neovascularization (CNV)
Species Mus musculus
Tissues/Cell_line RPE and choroids
Methods immunostaining, Western blot, histological analysis
Expression pattern associated
Functional description Even though eGFP expression in most cases was restricted to a limited number of RPE cells, significant reduction of CNV was obtained in eyes treated with miR(5,B,7) compared to the control group. These findings suggest that locally expressed miR(5,B,7) provides anti-angiogenic effect not only restricted to the transduced cells.
PubMed ID 28817343
Year 2017
Title Suppression of Choroidal Neovascularization in Mice by Subretinal Delivery of Multigenic Lentiviral Vectors Encoding Anti-Angiogenic MicroRNAs.
Drug-related ncRNA NO

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