|choroidal neovascularization (CNV)
|RPE and choroids
|immunostaining, Western blot, histological analysis
|Even though eGFP expression in most cases was restricted to a limited number of RPE cells, significant reduction of CNV was obtained in eyes treated with miR(5,B,7) compared to the control group. These findings suggest that locally expressed miR(5,B,7) provides anti-angiogenic effect not only restricted to the transduced cells.
|Suppression of Choroidal Neovascularization in Mice by Subretinal Delivery of Multigenic Lentiviral Vectors Encoding Anti-Angiogenic MicroRNAs.
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