|choroidal neovascularization (CNV)
|human umbilical vein endothelial cells (HUVECs)
|siRNA transfection, angiogenic sprouting assay
|siRNA-mediated Brag2-silencing reduced EC angiogenic sprouting and migration. Brag2-siRNA transfection differentially affected α5β1- and αVβ3-integrin function. In vivo intravitreal injection of plasmids containing Brag2-shRNA reduced pathological ischemia-induced retinal and choroidal neovascularization.
|Brag2 differentially regulates β1- and β3-integrin-dependent adhesion in endothelial cells and is involved in developmental and pathological angiogenesis.
Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.