A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of choroidal neovascularization (CNV)
ncRNA name apelin siRNA
ncRNA Category siRNA
Disease name choroidal neovascularization (CNV)
Species Homo sapiens
Tissues/Cell_line human umbilical vein endothelial cells (HUVECs)
Methods qPCR, immunohistochemistry, flow cytometry, siRNA transfection, qRT-PCR, alamar Blue assay
Expression pattern associated
Functional description Apelin small and interfering RNA (siRNA) suppressed proliferation of endothelial cells independently of vascular endothelial growth factor (VEGF) receptor 2 signaling, while VEGF increased expression of apelin and APJ in human umbilical vein endothelial cells.
PubMed ID 23722395
Year 2013
Title Laser-induced choroidal neovascularization in mice attenuated by deficiency in the apelin-APJ system.
Drug-related ncRNA NO

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