|choroidal neovascularization (CNV)
|RPE cell line ARPE-19
|siRNA transfection, semi-qRT–PCR, Western blot, cell proliferation assay, migration assay, tube formation assay
|Knockdown of HO-1 expression and inhibition of HO-1 activity resulted in potent reduction of the expression of vascular endothelial growth factor (VEGF) under hypoxia. Furthermore, knockdown of HO-1 suppressed the proliferation, migration and tube formation of cocultured endothelial cells.
|Silencing heme oxygenase-1 gene expression in retinal pigment epithelial cells inhibits proliferation, migration and tube formation of cocultured endothelial cells.
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