A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of choroidal neovascularization (CNV)
ncRNA name CXCR4 siRNA
ncRNA Category siRNA
Disease name choroidal neovascularization (CNV)
Species Macaca mulatta
Tissues/Cell_line rhesus choroid-retinal endothelial cell line RF/6A
Methods siRNA transfection, qPCR, Western blot, flow cytometry
Expression pattern associated
Functional description SDF-1-induced cell proliferation was abolished after CXCR4 siRNA transfection. SDF-1 promoted RF/6A cell migration, but this was reversed by CXCR4 siRNA transfection. When the cells were transfected with both CXCR4 and CXCR7 siRNA, the stimulating effect of SDF-1 on RF/6A cell tube formation was totally abolished.
PubMed ID 23549077
Year 2013
Title CXCR7/CXCR4/CXCL12 axis regulates the proliferation, migration, survival and tube formation of choroid-retinal endothelial cells.
Drug-related ncRNA NO

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