|choroidal neovascularization (CNV)
|rhesus choroid-retinal endothelial cell line RF/6A
|siRNA transfection, qPCR, Western blot, flow cytometry
|SDF-1 significantly inhibited apoptosis of RF/6A cells. The anti-apoptotic effect was significantly attenuated after CXCR7 siRNA transfection. When the cells were transfected with both CXCR4 and CXCR7 siRNA, the stimulating effect of SDF-1 on RF/6A cell tube formation was totally abolished.
|CXCR7/CXCR4/CXCL12 axis regulates the proliferation, migration, survival and tube formation of choroid-retinal endothelial cells.
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