| ncRNA name | CRYAB siRNA |
| ncRNA Category | siRNA |
| Disease name | choroidal neovascularization (CNV) |
| Species | Mus musculus |
| Tissues/Cell_line | retinas, RPE/choroids |
| Methods | siRNA injection, qRT-PCR, immunohistochemistry |
| Expression pattern | associated |
| Functional description | siRNA knockdown or pharmacological blockade of IRE1α, ATF6, or CRYAB increased intracellular VEGF degradation and decreased full-length intracellular VEGF. Inhibition of IRE1α, ATF6, or CRYAB resulted in an approximately 40% reduction of in vitro angiogenesis, which was further reduced in combination with a neutralizing antibody against extracellular VEGF. |
| PubMed ID | 23395094 |
| Year | 2013 |
| Title | Targeting the IRE1α/XBP1 and ATF6 arms of the unfolded protein response enhances VEGF blockade to prevent retinal and choroidal neovascularization. |
| Drug-related ncRNA | NO |
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