A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of choroidal neovascularization (CNV)
ncRNA name mmu-miR-195a-3p
ncRNA Category miRNA
Disease name choroidal neovascularization (CNV)
Species Mus musculus
Tissues/Cell_line mesenchymal stem cells (MSCs)
Methods Transient transfection, qRT-PCR, Western blot, luciferase reporter assay
Expression pattern down-regulated
Functional description Matrix metalloproteinase 2 (Mmp2) transcript is a target of miR-195a-3p, and that silencing Mmp2 phenocopied the reduced proliferation and migration of MSCs. The therapeutic potential of miR-195a-3p as an angiogenesis inhibitor was also demonstrated in a laser-induced choroidal neovascularization mouse model.
PubMed ID 26989874
Year 2016
Title MicroRNA-195a-3p inhibits angiogenesis by targeting Mmp2 in murine mesenchymal stem cells.
Drug-related ncRNA NO

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