A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of choroidal neovascularization (CNV)
ncRNA name BACE1 siRNA
ncRNA Category siRNA
Disease name choroidal neovascularization (CNV)
Species Bos taurus
Tissues/Cell_line bovine retinal microvascular endothelial cells
Methods immunohistochemistry, qPCR, immunoprecipitation, Western blot, siRNA transfection
Expression pattern associated
Functional description BACE1 plays a critical role in retinal homeostasis. Intravitreal administration of BACE1 inhibitor or BACE1 small interfering RNA (siRNA) increases choroidal neovascularization in mice.
PubMed ID 22903875
Year 2012
Title β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment.
Drug-related ncRNA NO

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