A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of choroidal neovascularization (CNV)
ncRNA name Smad5 siRNA
ncRNA Category siRNA
Disease name choroidal neovascularization (CNV)
Species Homo sapiens
Tissues/Cell_line human fetal RPE cells
Methods fluorescein angiogram, immunohistochemistry, qRT-PCR, ELISA, Western blot, zymography, siRNA transfection
Expression pattern associated
Functional description Our studies identified an anti-angiogenic role for BMP4 in laser-induced CNV, mediated by direct inhibition of MMP-9 and indirect inhibition of VEGF. The inhibition of MMP-9 was Smad-dependent because BMP4 failed to repress TNF-induced MMP-9 expression when Smad1,5 was silenced by siRNA.
PubMed ID 22392094
Year 2012
Title Over-expression of BMP4 inhibits experimental choroidal neovascularization by modulating VEGF and MMP-9.
Drug-related ncRNA NO

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